Environmental Influences on the Epigenome: a Scoping Report
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منابع مشابه
Environmental influences on the female epigenome and behavior
Environmental factors have long-lasting effects on brain development and behavior. One way experiences are propagated is via epigenetic modifications to the genome. Environmentally-driven epigenetic modifications show incredible brain region- and sex-specificity, and many brain regions affected are ones involved in maternal behavior. In rodent models, females are typically the primary caregiver...
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The environment is a well-established source of damaging or disrupting influences on cellular function. In the past, studies of the mechanisms by which such disruptions occur have focused largely on either direct toxic effects on cellular function at the protein or cell signaling level, or mutagenic effects that impact the genome. In recent years there has been a growing appreciation for the po...
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Herpetofauna (amphibians and reptiles) and fish represent important sentinel and indicator species for environmental and ecosystem health. It is widely accepted that the epigenome plays an important role in gene expression regulation. Environmental stimuli, including temperature and pollutants, influence gene activity, and there is growing evidence demonstrating that an important mechanism is t...
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Epigenetics is being increasingly combined with epidemiology to add mechanistic understanding to associations observed between environmental, genetic and stochastic factors and human disease phenotypes. Currently, epigenetic epidemiological studies primarily focus on exploring if and where the epigenome (i.e. the overall epigenetic state of a cell) is influenced by specific environmental exposu...
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BACKGROUND Characterization of the epigenome is a primary interest for children's environmental health researchers studying the environmental influences on human populations, particularly those studying the role of pregnancy and early-life exposures on later-in-life health outcomes. OBJECTIVES Our objective was to consider the state of the science in environmental epigenetics research and to ...
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